Slow dynamics in features of synchronized neural network responses
نویسندگان
چکیده
In this report trial-to-trial variations in the synchronized responses of neural networks are explored over time scales of minutes, in ex-vivo large scale cortical networks. We show that sub-second measures of the individual synchronous response, namely-its latency and decay duration, are related to minutes-scale network response dynamics. Network responsiveness is reflected as residency in, or shifting amongst, areas of the latency-decay plane. The different sensitivities of latency and decay durations to synaptic blockers imply that these two measures reflect aspects of inhibitory and excitatory activities. Taken together, the data suggest that trial-to-trial variations in the synchronized responses of neural networks might be related to effective excitation-inhibition ratio being a dynamic variable over time scales of minutes.
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